It has been 50 years since Francis Fontan pioneered the operation that today bears his
name. Initially designed for patients with tricuspid atresia, this procedure is now offered for a …

Life expectancy and quality of life for those born with congenital heart disease (CHD) have
greatly improved over the past 3 decades. While representing a great advance for these …

Background—Plastic bronchitis is a potentially fatal disorder occurring in children with single-
ventricle physiology, and other diseases, as well, such as asthma. In this study, we report …

Background—Fetal aortic valvuloplasty can be performed for severe midgestation aortic
stenosis in an attempt to prevent progression to hypoplastic left heart syndrome (HLHS). A …

For pediatric rare diseases, the number of patients available to support traditional research
methods is often inadequate. However, patients who have similar diseases cluster “virtually” …

Lymphatic flow disorders include a broad spectrum of abnormalities that can originate in the
lymphatic or the venous system. The development of these disorders is multifactorial and is …

Objective To characterize the medical history, disease progression, and treatment of current-
era patients with the rare diseases Fontan-associated protein-losing enteropathy (PLE) and …

In patients with a functionally univentricular heart, the Fontan strategy achieves separation of
the systemic and pulmonary circulation and reduction of ventricular volume overload …

The Fontan operation, although part of a life-saving surgical strategy, manifests a variety of
end-organ complications and unique morbidities that are being recognised with increasing …

Background Early identification of plastic bronchitis (PB) is of great importance and may aid
in delivering appropriate treatment. This study aimed to develop and validate a nomogram …