The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and
immunosuppressive therapeutics in the 1940s and their continued use and development …

In animals, systemic control of metabolism is conducted by metabolic tissues and relies on
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …

Glucose-induced insulin secretion in response to a step increase in blood glucose
concentrations follows a biphasic time course consisting of a rapid and transient first phase …

The etiology of type 2 diabetes mellitus involves the induction of insulin resistance along
with the disruption of pancreatic β-cell function and the loss of β-cell mass. In addition to a …

The major goal in the treatment of type 2 diabetes mellitus is to control the hyperglycaemia
characteristic of the disease. However, treatment with common therapies such as insulin or …

Three-dimensional (3D) multicellular organoids recapitulate the native complexities of
human tissue better than traditional cellular monolayers. As organoids are insufficiently …

Statins are the gold-standard treatment for the prevention of primary and secondary
cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety …

The release of insulin from pancreatic islets requires negative regulation to ensure low
levels of insulin release under resting conditions, as well as positive regulation to facilitate …

Insulin is produced by pancreatic β-cells, and once released to the blood, the hormone
stimulates glucose uptake and suppresses glucose production. Defects in both the …