ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …

Apolipoprotein E (ApoE) is of great interest due to its role as a cholesterol/lipid transporter in
the central nervous system (CNS) and as the most influential genetic risk factor for Alzheimer …

Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer's disease (AD). The
production and deposition of Aβ are important factors affecting AD progression and …

Proprotein convertase subtilisin/kexin type 9 (PCSK9), mainly synthetized and released by
the liver, represents one of the key regulators of low-density lipoprotein cholesterol …

The most prevalent genetic risk factor for Alzheimer's disease (AD) is Apolipoprotein E
(ApoE), a gene located on chromosome 19 that encodes three alleles (e2, e3, and e4) that …

Synaptic transfer of tau has long been hypothesized from the human pathology pattern and
has been demonstrated in vitro and in vivo, but the precise mechanisms remain unclear …

Abstract The Apolipoprotein E ε4 (ApoE ε4) allele, encoding ApoE4, is the strongest genetic
risk factor for late-onset Alzheimer's disease (LOAD). Emerging epidemiological evidence …

Oxidative stress is associated with the progression of Alzheimer's disease (AD). Reactive
oxygen species can modify lipids, DNA, RNA, and proteins in the brain. The products of their …