Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …

The central role of oligomers, small soluble aggregates of misfolded proteins, in the
pathogenesis of neurodegenerative disorders is recognized in numerous experimental …

The amyloid-antimicrobial link hypothesis is based on antimicrobial properties found in
human amyloids involved in neurodegenerative and systemic diseases, along with …

Abstract α-Synuclein (αSyn) aggregation in Lewy bodies and neurites defines both familial
and 'sporadic'Parkinson's disease. We previously identified α-helically folded αSyn …

Summary α-Synuclein plays an important role in synaptic functions by interacting with
synaptic vesicle membrane, while its oligomers and fibrils are associated with several …

The protein α-synuclein, a key player in Parkinson's disease (PD) and other
synucleinopathies, exists in different physiological conformations: cytosolic unfolded …

While misfolding of alpha-synuclein (αSyn) is central to the pathogenesis of Parkinson's
disease (PD), fundamental questions about its structure and function at the synapse remain …

α-Synuclein (αS) plays a key role in Parkinson's disease. Although Parkinson's disease is
typically “sporadic,” inherited αS missense mutations provide crucial insights into molecular …

The formation of amyloid fibrils by α-synuclein (αS) protein inside the Lewy bodies and Lewy
neurites is the prominent pathological hallmark of Parkinson's disease (PD). The fibrillation …

α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under
physiological conditions. However, in several neurodegenerative diseases, including …