Conopeptides are a diverse group of recently evolved venom peptides used for prey capture
and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with …

Abstract Terlau, Heinrich, and Baldomero M. Olivera. Conus Venoms: A Rich Source of
Novel Ion Channel-Targeted Peptides. Physiol Rev 84: 41–68, 2004; 10.1152/physrev …

Covering: 2007. Previous review: Nat. Prod. Rep., 2008, 25, 35This review covers the
literature published in 2007 for marine natural products, with 948 citations (627 for the …

The oceans are a uniquely rich source of bioactive metabolites, of which sponges have
been shown to be among the most prolific producers of diverse bioactive secondary …

Conus venoms contain a remarkable diversity of pharmacologically active small peptides.
Their targets are ion channels and receptors in the neuromuscular system. The venom of …

N-Methyl-d-aspartate (NMDA) receptors are tetrameric ion channels containing two of four
possible GluN2 subunits. These receptors have been implicated for decades in neurological …

▪ Abstract The venoms of predatory cone snails represent a rich combinatorial-like library of
evolutionarily selected, neuropharmacologically active peptides. A major fraction of the …

It is now over 20 years since the first conotoxin was biochemically characterized,
establishing for the first time that an active component of a Conus venom was a small …

Over two decades of research on venom peptides derived from cone snails (“conopeptides
or conotoxins”) has led to several compounds that have reached human clinical trials, most …

We have purified contulakin-G, a 16-amino acid O-linked glycopeptide (pGlu-Ser-Glu-Glu-
Gly-Gly-Ser-Asn-Ala-Thr-Lys-Lys-Pro-Tyr-Ile-Leu-OH, pGlu is pyroglutamate) from Conus …