Purpose The current systematic review investigated the results of application of some of the
most commonly used scaffolds in conjugation with stem cells and growth factors in animal …

Recombinant human bone morphogenetic protein-2 and-7 were recently granted United
States Food and Drug Administration approval for select clinical applications in bone repair …

The regulation of mouse embryonic stem cell (mESC) fate is controlled by the interplay of
signaling networks that either promote self-renewal or induce differentiation. Leukemia …

Major drawbacks of using an autograft are the possibilities of insufficient bony source and
patient's morbidity after operation. Bone tissue engineering technology, therefore, has been …

Embryonic stem cells represent a potentially unlimited cell source for tissue engineering
applications. However, in order to be used for such applications, embryonic stem cells' …

Bone remodeling involves synthesis of organic matrix by osteoblasts and bone resorption by
osteoclasts. A tight collaboration between these two cell types is essential to maintain a …

Introduction: Bone grafting is used to repair large bone defects and autograft is recognised
as producing the best clinical outcome, which is partly due to its cellular component. When …

Controlled differentiation of embryonic stem cells (ESC) is necessary to their use as a cell
source for tissue engineering or regeneration. To date, most studies have concentrated on …

Object There is currently no biologic therapy to repair or restore a degenerated intervertebral
disc. A potential solution may rest with embryonic stem cells (ESCs), which have a potential …

We developed a new and efficient method for osteoblastic differentiation of human
embryonic stem cells (hESCs) using primary bone-derived cells (PBDs). Three days after …