A brief introduction to chemical reaction optimization

CJ Taylor, A Pomberger, KC Felton, R Grainger… - Chemical …, 2023 - ACS Publications
From the start of a synthetic chemist's training, experiments are conducted based on recipes
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …

Application of quality by design in optimization of nanoformulations: Principle, perspectives and practices

D Birla, N Khandale, B Bashir, M ShahbazAlam… - Drug Delivery and …, 2024 - Springer
Nanoparticulate drug delivery systems (NDDS) based nanoformulations have emerged as
promising drug delivery systems. Various NDDS-based formulations have been reported …

Design of experiments in pharmaceutical development

AS Dhoot, GJ Fernandes, A Naha… - Pharmaceutical …, 2019 - Springer
In order to develop high-quality pharmaceutical products, a traditional approach based the
univariate or trial and error method was used in the past that led to several problems like …

Formulation development and evaluation of microemulsion based lornoxicam gel

NA Thombre, PS Niphade, ED Ahire… - Biosciences …, 2022 - biotech-asia.org
The objective of the existing research was formulation development and preparation of
microemulsion loaded emulgel in augmenting the topical delivery of Lornoxicam. Emulsion …

Design and evaluation of mucoadhesive microemulsion for neuroprotective effect of ibuprofen following intranasal route in the MPTP mice model

S Mandal, SD Mandal, K Chuttani… - Drug development …, 2016 - Taylor & Francis
Background: The present study is to investigate the neuroprotective effect of ibuprofen by
intranasal administration of mucoadhesive microemulsion (MMEI) against inflammation …

Enhancing Microemulsion-Based Therapeutic Drug Delivery: Exploring Surfactants, Co-Surfactants, and Quality-by-Design Strategies within Pseudoternary Phase …

A Bamanna, A Rajora, K Nagpal - Critical Reviews™ in …, 2025 - dl.begellhouse.com
Microemulsions (MEs) are homogeneous, isotropic, transparent, and thermodynamically
stable mixtures of water, oil, and surfactants. Their unique properties have garnered …

Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat inflammation for treatment of rheumatoid arthritis

M Naeem, T Iqbal, Z Nawaz, S Hussain - Anais da Academia …, 2021 - SciELO Brasil
The purpose of present study was to prepare transdermal therapeutic system that could
enhance dissolution of poorly aqueous soluble drug Celecoxib and thus increase its skin …

Peranan Metode Desain Eksperimen dalam Formulasi Sediaan Farmasi

T Permana, F Darusman - Jurnal Riset Farmasi, 2023 - journals.unisba.ac.id
To develop high-quality pharmaceutical products, traditional approaches based on
univariate or trial-and-error methods that cause some problems such as non-reproducible …

Preparation, optimization and evaluation of Osthole transdermal therapeutic system

M Naeem, T Iqbal, M Yousuf, Z Nawaz… - Anais da Academia …, 2023 - SciELO Brasil
In the current study, the solubility and permeability of Osthole-loaded microemulsion were
enhanced, which increased bioavailability. In addition, Carbomer 940 was added for …

[HTML][HTML] Preclinical study of ibuprofen loaded transnasal mucoadhesive microemulsion for neuroprotective effect in MPTP mice model

S Mandal, SD Mandal, K Chuttani… - Iranian Journal of …, 2018 - ncbi.nlm.nih.gov
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), showed very promising
neuroprotection action, but it suffers from high first pass metabolism and limited ability to …