Metabolomics is a rapidly growing field consisting of the analysis of a large number of
metabolites at a system scale. The two major goals of metabolomics are the identification of …

At different stages of any research project, molecular biologists need to choose—often
somewhat arbitrarily, even after careful statistical data analysis—which genes or proteins to …

Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To
identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes …

There are currently few therapeutic options for patients with pancreatic cancer, and new
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end …

Crosstalk and complexity within signaling pathways and their perturbation by oncogenes
limit component-by-component approaches to understanding human disease. Network …

Alterations in gut microbiome composition have an emerging role in health and disease
including brain function and behavior. Short chain fatty acids (SCFA) like propionic (PPA) …

The malignant brain cancer medulloblastoma is characterized by mutations in Hedgehog
(Hh) signaling pathway genes, which lead to constitutive activation of the G protein …

Genome-wide association studies (GWAS) have identified loci reproducibly associated with
pulmonary diseases; however, the molecular mechanism underlying these associations are …

Novel therapeutics in areas with a high unmet medical need are based on innovative drug
targets. Although 'biologicals' have enlarged the space of druggable molecules, the number …

Recognition of some of the limitations of target-based drug discovery has recently led to the
renaissance of a more holistic approach in which complex biological systems are …