Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Aging trajectories vary among individuals, characterized by progressive functional decline,
often leading to disease states. One of the central hallmarks of aging is the deterioration of …

In humans, aggregation of polyglutamine repeat (polyQ) proteins causes disorders such as
Huntington's disease. Although plants express hundreds of polyQ-containing proteins, no …

The prevalence of neurodegenerative disorders such as Alzheimer's and Parkinson's
disease are rising globally. The role of environmental pollution in neurodegeneration is …

The majority of severe early-onset and juvenile cases of amyotrophic lateral sclerosis (ALS)
are caused by mutations in the FUS gene, resulting in rapid disease progression. Mutant …

The genome of Caenorhabditis elegans encodes 284 nuclear hormone receptor, which
perform diverse functions in development and physiology. One of the best characterized of …

The proteasome, a complex multi-catalytic protease machinery, orchestrates the protein
degradation essential for maintaining cellular homeostasis, and its dysregulation also …

Aging is a major risk factor for many diseases. Recent studies have shown that age-related
disruption of proteostasis leads to the accumulation of abnormal proteins and that …

Objective Hexanucleotide repeat expansions in the C9orf72 gene are the most common
genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A …

Cold temperatures have been shown to slow skin wound healing. However, the specific
mechanisms underlying cold-induced impairment of wound healing remain unclear. Here …