Animal models of substance use disorders have been criticized for their limited translation.
One important factor behind seeking and taking that has so far been largely overlooked is …

Rationale Female rodents consume more ethanol (EtOH) than males and exhibit greater
aversion-resistant drinking in some paradigms. Ovarian hormones promote EtOH drinking …

Alcohol use disorder extracts substantial personal, social and clinical costs, and continued
intake despite negative consequences (compulsion-like consumption) can contribute …

The prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for
neuroadaptations in alcohol use disorders. Recent advances in genetically encoded …

Combined use of fentanyl and methamphetamine (FENT+ METH) has increased in recent
years and has been documented in a growing number overdose deaths each year. The …

A key facet of alcohol use disorder is continuing to drink alcohol despite negative
consequences (so called “aversion-resistant drinking”). In this study, we sought to assess …

Opioid use disorder (OUD) is a chronic condition associated with long-lasting molecular and
behavioral changes. Animals with prolonged access to opioids develop behaviors similar to …

Alcohol use disorder (AUD) is a chronic, relapsing disorder characterized by an escalation
of drinking and the emergence of negative affective states over time. Within this framework …

Background Behavioral tolerance to alcohol underscores the widely accepted notion that
individuals who regularly drink alcohol become less sensitive to its impairing effects …

Neural measures of alcohol cue incentive salience have been associated with retrospective
reports of riskier alcohol use behaviour and subjective response profiles. This study tested …