CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

Cancer is a leading cause of death worldwide. Cancer cells proliferate uncontrollably and,
many cases, spread to other parts of the body. A protein historically involved in cancer is …

A major limitation of targeted cancer therapy is the rapid emergence of drug resistance,
which often arises through mutations at or downstream of the drug target or through intrinsic …

Proper DNA damage response is essential for the maintenance of genome integrity. The E3
ligase RNF168 deficiency fully prevents both the initial recruitment and retention of 53BP1 at …

The glutathione peroxidase homologs (GPxs) efficiently reduce hydroperoxides using
electrons from glutathione (GSH), thioredoxin (Trx), or protein disulfide isomerase (PDI). Trx …

Background. Lysine‐specific demethylase 1A (KDM1A) is a histone demethylation enzyme
and a crucial epigenetic factor for multiple pathological pathways that mediate …

Background Protein kinase CK2 is a ubiquitous and highly conserved protein Ser/Thr kinase
with diverse cell functions. CK2 is upregulated in various cancers and affects numerous …

Post-translational modifications (PTMs) of proteins play a crucial role in living organisms,
altering the properties and functions of proteins. There are over 450 known PTMs involved in …

Follicle selection in chicken refers to the process of selecting a follicle to enter hierarchy from
a cohort of small yellow follicles (SY) with a diameter of 6 to 8 mm. The follicle being …