Genetic variants are traditionally known to shape the susceptibility to neuropsychiatric
disorders. An increasing number of studies indicate that remodeling of the gut microbiome …

Genome-wide association studies (GWAS) have reported substantial genomic loci
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …

Functional changes of white matter are largely unexplored in patients with psychiatric
disorders. This study examined white matter dysfunctions common in four major psychiatric …

Bipolar disorder (BD) is a neuropsychiatric mood disorder manifested by recurrent episodes
of mania and depression. More than half of BD patients are non-responsive to lithium, the …

Background Choosing the appropriate antipsychotic drug (APD) treatment for patients with
schizophrenia (SCZ) can be challenging, as the treatment response to APD is highly …

Objective Mechanisms underlying the adolescent‐onset and early‐onset gout are unclear.
This study aimed to discover variants associated with early‐onset gout. Methods We …

Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of
lithium ions on mood regulation in bipolar disorder and other mental illnesses, including …

Bipolar disorder (BD) and obesity are highly comorbid. We previously performed a genome-
wide association study (GWAS) for BD risk accounting for the effect of body mass index …

Bipolar disorder (BD) profoundly affects cognitive and psychosocial functioning, leading to a
significant illness burden on patients and their families. Genetic factors are predominant in …

Background Opioid use disorder (OUD), a serious health burden worldwide, is associated
with lower cognitive function. Recent studies have demonstrated a negative genetic …