Genomics, convergent neuroscience and progress in understanding autism spectrum disorder
More than a hundred genes have been identified that, when disrupted, impart large risk for
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …
Genetic causes and modifiers of autism spectrum disorder
L Rylaarsdam, A Guemez-Gamboa - Frontiers in cellular …, 2019 - frontiersin.org
Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …
Sex differences in autism spectrum disorder: a review
Abstract Purpose of Review Neurodevelopmental disorders disproportionately affect males.
The mechanisms underlying male vulnerability or female protection are not known and …
The mechanisms underlying male vulnerability or female protection are not known and …
Zebrafish in toxicology and environmental health
K Bambino, J Chu - Current topics in developmental biology, 2017 - Elsevier
As manufacturing processes and development of new synthetic compounds increase to
keep pace with the expanding global demand, environmental health, and the effects of …
keep pace with the expanding global demand, environmental health, and the effects of …
[PDF][PDF] A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior
Sex hormones exert a profound influence on gendered behaviors. How individual sex
hormone-responsive neuronal populations regulate diverse sex-typical behaviors is unclear …
hormone-responsive neuronal populations regulate diverse sex-typical behaviors is unclear …
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes
Hundreds of human genes are associated with neurological diseases, but translation into
tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to …
tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to …
Autism spectrum disorder genetics and the search for pathological mechanisms
Recent progress in the identification of genes and genomic regions contributing to autism
spectrum disorder (ASD) has had a broad impact on our understanding of the nature of …
spectrum disorder (ASD) has had a broad impact on our understanding of the nature of …
Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience
Gene Ontology analyses of autism spectrum disorders (ASD) risk genes have repeatedly
highlighted synaptic function and transcriptional regulation as key points of convergence …
highlighted synaptic function and transcriptional regulation as key points of convergence …
The road to precision psychiatry: translating genetics into disease mechanisms
Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …
Zebrafish behavior: opportunities and challenges
MB Orger, GG de Polavieja - Annual review of neuroscience, 2017 - annualreviews.org
A great challenge in neuroscience is understanding how activity in the brain gives rise to
behavior. The zebrafish is an ideal vertebrate model to address this challenge, thanks to the …
behavior. The zebrafish is an ideal vertebrate model to address this challenge, thanks to the …