Messenger RNAs (mRNAs) are formed in the nuclei of eukaryotic cells extensive
posttranscriptional processing of primary transcripts of protein-coding genes (1, 2). These …

Distinct profiles of autoantibodies directed to intracellular antigens can be detected in the
systemic connective tissue diseases. They aid in establishing the correct diagnosis and are …

Spinal muscular atrophy (SMA), one of the most common fatal autosomal recessive
diseases, is characterized by degeneration of motor neurons and muscular atrophy. The …

Spinal muscular atrophy (SMA) is a common motor neuron degenerative disease that results
from reduced levels of, or mutations in, the Survival of Motor Neurons (SMN) protein. SMN is …

snRNPs, integral components of the pre-mRNA splicing machinery, consist of seven Sm
proteins which assemble in the cytoplasm as a ring structure on the snRNAs U1, U2, U4 …

SC‐35 is a non‐snRNP spliceosome component that is specifically recognized by the anti‐
spliceosome monoclonal antibody alpha SC‐35. In this paper we provide direct evidence …

The casein kinase I family of serine/threonine protein kinases is highly conserved from yeast
to humans. Until only recently, both the function and regulation of these enzymes remained …

The survival of motor neurons (SMN) gene is the disease gene of spinal muscular atrophy
(SMA), a common motor neuron degenerative disease. The SMN protein is part of a complex …

Components of the pre‐mRNA splicing machinery are localized in interchromatin granule
clusters (IGCs) and perichromatin fibrils (PFs). Here we report the biochemical purification of …

We have recently shown that discrete foci are present in the nuclei of mammalian cells in
which each of the U1, U2, U4/U6, and U5 snRNPs involved in pre-mRNA splicing, and the …