Wound healing is one of the most complex biological processes to occur in life. Repair of
tissue following injury involves dynamic interactions between multiple cell types, growth …

The bioavailability of members of the transforming growth factor β (TGF-β) family is
controlled by a number of mechanisms. Bona fide TGF-β is sequestered into the matrix in a …

Alveolar macrophages (AMs) derive from fetal liver monocytes, which colonize the lung
during embryonic development and give rise to fully mature AMs perinatally. AM …

The cytokine TGF-β plays an integral role in regulating immune responses. TGF-β has
pleiotropic effects on adaptive immunity, especially in the regulation of effector and …

Genetic studies in animals and humans indicate that gene mutations that functionally perturb
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …

Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with
global inhibitors of TGF-β have been disappointing, suggesting that a more targeted …

The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

The Integrin v 6 Binds and Activates Latent TGF 1: A Mechanism for Regulating Pulmonary
Inflammation and Fibrosis Page 1 Cell, Vol. 96, 319–328, February 5, 1999, Copyright ©1999 …

▪ Abstract The transforming growth factor β (TGF-β) family of proteins are a set of pleiotropic
secreted signaling molecules with unique and potent immunoregulatory properties. TGF-β1 …

Transforming growth factor β (TGF-β) has long been implicated in fibrotic diseases, including
the multisystem fibrotic disease systemic sclerosis (SSc). Expression of TGF-β-regulated …