Abstract Avila, Jesús, José J. Lucas, Mar Pérez, and Félix Hernández. Role of Tau Protein in
Both Physiological and Pathological Conditions. Physiol Rev 84: 361–384, 2004; …

Alzheimer disease (AD) is the most common cause of dementia in adults. The current
therapy for AD has only moderate efficacy in controlling symptoms, and it does not cure the …

Clinical and epidemiological studies have found that type 2 diabetes, and
hyperinsulinaemia, increased the risk of developing Alzheimer's disease (AD) in the elderly …

In the adult mammalian brain, more than 250 protein kinases are expressed, but only a few
of these kinases are currently known to enable learning and memory. Based on this …

Abstract Cyclin-dependent kinase 5 (Cdk5) and its regulatory subunit p35 are integral
players in the proper development of the mammalian central nervous system. Proteolytic …

Microtubule-associated protein tau undergoes several post-translational modifications and
aggregates into paired helical filaments (PHFs) in Alzheimer's disease (AD) and other …

The microtubule-associated protein tau, abundant in neurons, has gained notoriety due to
the fact that it is deposited in cells as fibrillar lesions in numerous neurodegenerative …

ABSTRACT Cyclin dependent kinase-5 (Cdk5), a family member of the cyclin-dependent
kinases, plays a pivotal role in the central nervous system. During embryogenesis, Cdk5 is …

While deregulation of cyclin-dependent kinase 5 (Cdk5) has been implicated in
neurodegenerative diseases, its precise role in synaptic plasticity and memory remains …

Microtubule-associated protein tau is abnormally hyperphosphorylated, glycosylated, and
aggregated in affected neurons in the brains of individuals with Alzheimer's disease (AD) …