Diabetes is a complex disease that affects over 400 million people worldwide. The life-long
insulin injections and continuous blood glucose monitoring required in type 1 diabetes …

Complex barriers separate immune-privileged tissues from the circulation. Here, we propose
that cell entry to immune-privileged sites through barriers composed of tight junction …

The eye is a sensory organ exposed to the environment and protected by a mucosal tissue
barrier. While it shares a number of features with other mucosal tissues, the ocular mucosal …

Most higher animals require sight for survival, yet even minor distortions of the visual axis
can cause blindness. For this reason, intraocular inflammation is incompatible with good …

Corneal transplantation is the most successful solid organ transplantation performed in
humans. The extraordinary success of orthotopic corneal allografts, in both humans and …

Primary immune responses are initiated by dendritic cells (DCs), which inform naive T
helper (Th) cells about invading pathogens, providing an antigen-specific 'signal 1'and a …

Immune-mediated inflammation and allograft rejection are greatly reduced in certain organs,
a phenomenon called'immune privilege'. Immune privilege is well developed in three …

First identified by Said and Mutt some 30 years ago, the vasoactive intestinal peptide (VIP)
was originally isolated as a vasodilator peptide. Subsequently, its biochemistry was …

Endophthalmitis is a severe inflammation of the interior of the eye caused by the introduction
of contaminating microorganisms following trauma, surgery, or hematogenous spread from a …

Liposomal formulations were significantly explored over the last decade for the ophthalmic
drug delivery applications. These formulations are mainly composed of phosphatidylcholine …