R Shechter, A London, M Schwartz - Nature Reviews Immunology, 2013 - nature.com
Complex barriers separate immune-privileged tissues from the circulation. Here, we propose that cell entry to immune-privileged sites through barriers composed of tight junction …
The eye is a sensory organ exposed to the environment and protected by a mucosal tissue barrier. While it shares a number of features with other mucosal tissues, the ocular mucosal …
Most higher animals require sight for survival, yet even minor distortions of the visual axis can cause blindness. For this reason, intraocular inflammation is incompatible with good …
J Hori, T Yamaguchi, H Keino, P Hamrah… - Progress in retinal and …, 2019 - Elsevier
Corneal transplantation is the most successful solid organ transplantation performed in humans. The extraordinary success of orthotopic corneal allografts, in both humans and …
Primary immune responses are initiated by dendritic cells (DCs), which inform naive T helper (Th) cells about invading pathogens, providing an antigen-specific 'signal 1'and a …
Immune-mediated inflammation and allograft rejection are greatly reduced in certain organs, a phenomenon called'immune privilege'. Immune privilege is well developed in three …
First identified by Said and Mutt some 30 years ago, the vasoactive intestinal peptide (VIP) was originally isolated as a vasodilator peptide. Subsequently, its biochemistry was …
MC Callegan, M Engelbert, DW Parke… - Clinical microbiology …, 2002 - Am Soc Microbiol
Endophthalmitis is a severe inflammation of the interior of the eye caused by the introduction of contaminating microorganisms following trauma, surgery, or hematogenous spread from a …
GP Mishra, M Bagui, V Tamboli… - Journal of drug …, 2011 - Wiley Online Library
Liposomal formulations were significantly explored over the last decade for the ophthalmic drug delivery applications. These formulations are mainly composed of phosphatidylcholine …