An abundance of data indicates there are sex differences in endogenous opioid peptides
and opioid receptors, leading to functional differences in sensitivity to opioid receptor …

The proteolytic processing of neuropeptides has an important regulatory function and the
peptide fragments resulting from the enzymatic degradation often exert essential …

Spinocerebellar ataxias (SCAs) are dominantly inherited neurodegenerative disorders
characterized by progressive cerebellar ataxia and dysarthria. We have identified missense …

Biosynthetic pathways for the formation of neuroactive peptides and the processes for their
inactivation include several enzymatic steps. In addition to enzymatic processing and …

The opioid peptides dynorphins may be involved in pathogenesis of Alzheimer disease (AD)
by inducing neurodegeneration or cognitive impairment. To test this hypothesis, the …

The skin is the largest and a remarkably plastic organ that serves as a protective barrier
against environmental stimuli and injuries throughout life. Skin injuries are serious health …

Opioid peptides were analysed in tissue extracts of various brain structures and the pituitary
gland from rats sacrificed by microwave irradiation, and compared with peptide levels in …

Abstract I. Introduction II. AAS May Lead to Opioid Dependence III. Interactions Between
AAS and the Endogenous Opioids A. The Endogenous Opioid Systems B. Effects of AAS on …

The biotransformation of the opioid peptide dynorphin A (1–17) was investigated in striatum
of freely moving Fischer rats, by direct infusion of this peptide, followed by recovery of the …

The in vivo biotransformation of dynorphin A (1–17)(Dyn A) was studied in the striatum of
hemiparkinsonian rats by using microdialysis in combination with nanoflow reversed‐phase …