The major targets for antibiotics in staphylococci are (i) the cell envelope,(ii) the ribosome and (iii) nucleic acids. Several novel targets emerged from recent targeted drug discovery …
A Beceiro, M Tomás, G Bou - Clinical microbiology reviews, 2013 - Am Soc Microbiol
Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria have modified their virulence mechanisms to adapt to host defense systems. Although the …
H McCarthy, JK Rudkin, NS Black… - Frontiers in cellular …, 2015 - frontiersin.org
Antibiotic resistance and biofilm-forming capacity contribute to the success of Staphylococcus aureus as a human pathogen in both healthcare and community settings …
During the 1990s, various reports of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections appeared in the literature, caused by novel …
M Otto - Cellular microbiology, 2012 - Wiley Online Library
Methicillin‐resistant S taphylococcus aureus (MRSA) is one of the most frequent causes of hospital‐and community‐associated infections. Resistance to the entire class of β‐lactam …
Staphylococcus aureus and Staphylococcus epidermidis are the most important etiological agents of biofilm associated-infections on indwelling medical devices. Biofilm infections may …
The epidemic community-associated methicillin-resistant Staphylococcus aureus (CA- MRSA) USA300 lineage has recently become a leading cause of hospital-associated …
D Bronesky, Z Wu, S Marzi, P Walter… - Annual review of …, 2016 - annualreviews.org
Staphylococcus aureus RNAIII is one of the main intracellular effectors of the quorum- sensing system. It is a multifunctional RNA that encodes a small peptide, and its noncoding …
M Laabei, M Recker, JK Rudkin, M Aldeljawi… - Genome …, 2014 - genome.cshlp.org
Microbial virulence is a complex and often multifactorial phenotype, intricately linked to a pathogen's evolutionary trajectory. Toxicity, the ability to destroy host cell membranes, and …