The importance of plasma protein binding (PPB) in modulating the effective drug
concentration at pharmacological target sites has been the topic of significant discussion …

Accumulating evidence suggests that diet and lifestyle can play an important role in delaying
the onset or halting the progression of age‐related health disorders and to improve cognitive …

Purpose More than 15 years have passed since the first description of the unbound brain-to-
plasma partition coefficient (Kp, uu, brain) by Prof. Margareta Hammarlund-Udenaes, which …

An accurate means of predicting blood–brain barrier (BBB) penetration and blood–brain
partitioning of NCEs (new chemical entities) would fulfill a major need in pharmaceutical …

Different polyphenol compounds are ingested when consuming a serving of fruits rich in
polyphenols, spanning from one-phenol hydroxybenzoic acid to more complex polymeric …

Although several epidemiological and intervention studies suggest that polyphenols (PPs)
and PP-rich foods may improve memory and cognition in animals and humans, PPs' mode …

New experimental methodologies were applied to measure the unbound brain-to-plasma
concentration ratio (K p, uu, brain) and the unbound CSF-to-plasma concentration ratio (K p …

Purpose: p53 pathway alterations are key molecular events in glioblastoma (GBM). MDM2
inhibitors increase expression and stability of p53 and are presumed to be most efficacious …

Flavonoids are a class of plant-derived dietary polyphenols that have attracted attention for
their pro-cognitive and anti-inflammatory effects. The diversity of flavonoids and their …

The brain is the most important organ in our body requiring its unique microenvironment. By
the virtue of its function, the blood-brain barrier poses a significant hurdle in drug delivery for …