Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Neuroinflammation regulated by microglia is one of the important factors involved in the
pathogenesis of Alzheimer's disease (AD). Activated microglia exhibited phenotypes termed …

ATP is a (co) transmitter and signaling molecule in the CNS. It acts at a multitude of ligand-
gated cationic channels termed P2X to induce rapid depolarization of the cell membrane …

Abstract The purinoceptor P2X 7 R is a promising therapeutic target for tauopathies,
including Alzheimer's disease (AD). Pharmacological inhibition or genetic knockdown of …

Various age-related diseases involve systemic inflammation, ie a stereotyped series of acute
immune system responses, and aging itself is commonly associated with low-grade …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder; it is the most
common cause of dementia and has no treatment. It is characterized by two pathological …

Calcium signaling is critical to neuronal function and regulates highly diverse processes
such as gene transcription, energy production, protein handling, and synaptic structure and …

Astrocytes are key homeostatic and defensive cells of the central nervous system (CNS).
They undertake numerous functions during development and in adulthood to support and …

Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-
sensitive classes broadly interfere with cognitive processes both under quasi normal and …