In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

Biology spans a continuum of length and time scales. Individual experimental methods only
glimpse discrete pieces of this spectrum but can be combined to construct a more holistic …

Respiratory infections cause significant morbidity and mortality, yet it is unclear why some
individuals succumb to severe disease. In patients hospitalized with avian A (H7N9) …

Despite advances in virological sciences and antiviral research, viruses continue to emerge,
circulate, and threaten public health. We still lack a comprehensive understanding of how …

Protein-mediated membrane fusion is the dynamic process where specialized protein
machinery undergoes dramatic conformational changes that drive two membrane bilayers …

Highlights•Whole-cell and on-lamellae cryo-ET for structural studies of viral
infection.•Inactivation protocols for improved structural preservation and biosafety.•VLP and …

Hepatitis B virus (HBV) is an important human pathogen that chronically infects
approximately 250 million people in the world, resulting in~ 1 million deaths annually. This …

The CD225/Dispanin superfamily contains membrane proteins that regulate vesicular
transport and membrane fusion events required for neurotransmission, glucose transport …

MemBrain v2 is a deep learning-enabled program aimed at the efficient analysis of
membranes in cryo-electron tomography (cryo-ET). The final v2 release of MemBrain will …

Influenza virus pandemics are caused by viruses from animal reservoirs that adapt to
efficiently infect and replicate in human hosts. Here, we investigate whether Interferon …