Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung
cancers and is pathologically, molecularly, biologically and clinically very different from other …

Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

Background Small cell lung cancer (SCLC) is a deadly, high grade neuroendocrine (NE)
tumor without recognized morphologic heterogeneity. However, over 30 years ago we …

The proneural transcription factor Ascl1 coordinates gene expression in both proliferating
and differentiating progenitors along the neuronal lineage. Here, we used a cellular model …

Glial cells expressing neuron‐glial antigen 2 (NG2), also known as oligodendrocyte
progenitor cells (OPCs), play a critical role in maintaining brain health. However, their ability …

miR-132 and miR-212 are structurally related microRNAs that have been found to exert
powerful modulatory effects within the central nervous system (CNS). Notably, these …

Background The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis
and a key factor necessary for the reprogramming of permissive cell types to neurons …

Purpose: Offering self-sampling of cervico-vaginal material for high-risk human
papillomavirus (hrHPV) testing is an effective method to increase the coverage in cervical …

Some lineage-determining transcription factors are overwhelmingly important in directing
embryonic cells to a particular differentiation pathway, such as Ascl1 for nerve. They also …

High-risk preterm infants are affected by a higher incidence of cognitive developmental
deficits due to the unavoidable risk factor of oxygen toxicity. Caffeine is known to have a …