Increasing evidence suggests that the autism spectrum disorder (ASD) may be associated
with inborn errors of metabolism, such as disorders of amino acid metabolism and transport …

In the 1980s, after the mitochondrial DNA (mtDNA) had been sequenced, several diseases
resulting from mtDNA mutations emerged. Later, numerous disorders caused by mutations …

Urbanization drastically transforms landscapes, resulting in fragmentation, degradation, and
the loss of local biodiversity. Yet, urban environments also offer opportunities to observe …

Amino acid metabolism is essential for cell survival, while the byproduct ammonia is toxic
and can injure cellular longevity. Here we show that CD8+ memory T (TM) cells mobilize the …

Ammonia is toxic to fishes. Different fish have different defense strategies against ammonia,
so the mechanism of ammonia poisoning is different. In this study, yellow catfish were …

Enhancing the potency of mRNA therapeutics is an important objective for treating rare
diseases, since it may enable lower and less-frequent dosing. Enzyme engineering can …

Urea cycle impairment and its relationship to obesity and inflammation remained elusive,
partly due to the dramatic clinical presentation of classical urea cycle defects. We generated …

Plastic pollution in the world is widespread and growing. The environment is swamped with
nanoplastics (< 100 nm), and the health consequences of these less visible pollutants are …

Simple Summary This study showed that the chemical agents (FML, SCN, and urea) used in
food processing produced mild concentrations and exposure time-dependent toxicity in A …

Keratoconus (KC) is a progressive corneal degeneration characterized by structural
changes consisting of progressive thinning and steepening of the cornea. These alterations …