Background Bipolar disorder may be associated with peripheral immune system
dysfunction; however, results in individual studies are conflicting. Our aim was to …

Lithium is a well-established therapeutic option for the acute and long-term management of
bipolar disorder and major depression. More recently, based on findings from translational …

BACKGROUND: We conducted a meta-analysis of studies comparing cytokine
concentrations between patients with bipolar disorder (BD) and healthy control subjects …

Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high
individual and societal burden. While not all patients display overt markers of elevated …

Objective To determine clinical predictors of lithium response in bipolar disorder. Methods
Systematic review of studies examining clinical predictors of lithium response was …

Importance Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder
(BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30 …

Background Previous individual studies have shown the differences in inflammatory
cytokines and gray matter volumes between bipolar disorder (BD) and unipolar depression …

Objective Inflammatory cytokines have been suggested to be the trait or state markers of
bipolar disorder, but with inconsistent results. This may be related to small sample sizes and …

Developing a more comprehensive understanding of the physiological underpinnings of
mental illness, precision medicine has the potential to revolutionize psychiatric care. With …

In the last two decades, a growing body of evidence has shown that lithium has several
neuroprotective effects. Several neurobiological mechanisms have been proposed to …