The childhood-onset or juvenile idiopathic inflammatory myopathies (JIIMs) are a
heterogenous group of rare and serious autoimmune diseases of children and young …

Importance Autoimmune disorders can affect various organs and if refractory, can be life
threatening. Recently, CD19-targeting–chimeric antigen receptor (CAR) T cells were …

Purpose of review To identify clues to disease activity and discuss therapy options. Recent
findings The diagnostic evaluation includes documenting symmetrical proximal muscle …

In recent decades, several pieces of evidence have drawn greater attention to the topic of
innate immunity, in particular, interferon (IFN) and Interleukin 6 in the pathogenesis of …

CD8+ T cells are cytotoxic lymphocytes that destroy pathogen infected and malignant cells
through release of cytolytic molecules and proinflammatory cytokines. Although the role of …

Background Interstitial lung disease (ILD) is a frequently observed comorbidity in
autoimmune diseases such as dermatomyositis/polymyositis (DM/PM), and it is significantly …

In this study, we determined if B lymphocytosis may serve as a JDM biomarker for disease
activity. Children with untreated JDM were divided into two groups based on age-adjusted B …

Idiopathic inflammatory myopathies (IIMs) are chronic autoimmune disorders involving
multiple organs, such as the muscle, skin, lungs and joints. Although the detailed …

Objective Abnormalities and hyperactivation of B cells have been described in idiopathic
inflammatory myopathies (IIM). However, little is known about changes in the homeostasis of …

Juvenile dermatomyositis is characterized by childhood-onset chronic inflammation of the
muscles and skin, with potential involvement of other organs. Patients are at risk for long …