Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of
iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion …

Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …

Ferroptosis (FPT) is a form of cell death due to missed control of membrane lipid
peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO …

Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as
cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term …

Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …

The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …

Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …