The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

Restless legs syndrome (RLS) involves abnormal limb sensations that diminish with motor
activity, worsen at rest, have a circadian peak in expression in the evening and at night, and …

Restless legs syndrome (RLS), a common neurological sensorimotor disorder in western
countries, has gained more and more attention in Asian countries. The prevalence of RLS is …

Persistent inward currents (PICs) are present in many types of neurons and likely have
diverse functions. In spinal motoneurons, PICs are especially strong, primarily located in …

Therapy-related augmentation of the symptoms of restless legs syndrome (RLS) is an
important clinical problem reported in up to 60% of patients treated with levodopa and, to a …

Objective Using narrative review techniques, this paper evaluates the evidence for
separable underlying patho-mechanisms of periodic limb movements (PLMs) to separable …

Converging lines of evidence suggest a role for the mesolimbic dopamine system in the
response to somatic antidepressant therapies. Here, we review evidence suggesting that …

RLS is a genetically heterogeneous complex trait with high prevalence but large phenotype
variability. Current theories of RLS pathophysiology emphasize brain iron deficiency with …