Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …

The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Numerous studies demonstrate that neuroinflammation is a key player in the progression of
Alzheimer's disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore …

Alzheimer disease (AD) is the most common neurodegenerative disease. An imbalance
between the production and clearance of Aβ (amyloid beta) is considered to be actively …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …

In the present report, we extend previous findings in the 5XFAD mouse model and
demonstrate that these mice develop an age-dependent motor phenotype in addition to …

Alzheimer's disease is associated with a disruption of amyloid β (Aβ) homeostasis, resulting
in the accumulation and subsequent deposition of Aβ peptides within the brain. The …

Formation of new neurons in the adult brain takes place in the subventricular zone and in
the subgranule layer of the dentate gyrus throughout life. Neurogenesis is thought to play a …

Background Amyloid plaques, a pathological hallmark of Alzheimer's disease (AD), are
accompanied by activated microglia. The role of activated microglia in the pathogenesis of …

The mechanisms underlying ryanodine receptor (RyR) dysfunction associated with
Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 …