Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight

JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Optogenetic fMRI for brain-wide circuit analysis of sensory processing

JY Lee, T You, CW Woo, SG Kim - International Journal of Molecular …, 2022 - mdpi.com
Sensory processing is a complex neurological process that receives, integrates, and
responds to information from one's own body and environment, which is closely related to …

Aging-dependent loss of functional connectivity in a mouse model of Alzheimer's disease and reversal by mGluR5 modulator

F Mandino, X Shen, G Desrosiers-Grégoire… - Molecular …, 2024 - nature.com
Amyloid accumulation in Alzheimer's disease (AD) is associated with synaptic damage and
altered connectivity in brain networks. While measures of amyloid accumulation and …

Impairment of entorhinal cortex network activity in Alzheimer's disease

F Karimani, A Asgari Taei… - Frontiers in Aging …, 2024 - frontiersin.org
The entorhinal cortex (EC) stands out as a critical brain region affected in the early phases of
Alzheimer's disease (AD), with some of the disease's pathological processes originating …

Combining magnetic resonance imaging with readout and/or perturbation of neural activity in animal models: Advantages and pitfalls

L Kosten, SA Emmi, S Missault, GA Keliris - Frontiers in Neuroscience, 2022 - frontiersin.org
One of the main challenges in brain research is to link all aspects of brain function: on a
cellular, systemic, and functional level. Multimodal neuroimaging methodology provides a …

What N Is N-ough for MRI-Based Animal Neuroimaging?

J Grandjean, EMR Lake, M Pagani, F Mandino - Eneuro, 2024 - eneuro.org
Fueled by the recent and controversial brain-wide association studies in humans, the animal
neuroimaging community has also begun questioning whether using larger sample sizes is …

Novel inductively coupled ear-bars (ICEs) to enhance restored fMRI signal from susceptibility compensation in rats

Y Chen, Z Fernandez, N Scheel, M Gifani… - Cerebral …, 2024 - academic.oup.com
Functional magnetic resonance imaging faces inherent challenges when applied to deep-
brain areas in rodents, eg entorhinal cortex, due to the signal loss near the ear cavities …

Aberrant Connectivity Across the Lifespan in a Mouse Model of Alzheimer's Disease and Rescue by mGluR5 Modulator Treatment

F Mandino, X Shen, G Desrosiers-Gregoire… - bioRxiv, 2023 - biorxiv.org
Amyloid accumulation in Alzheimer's disease (AD) is associated with synaptic damage and
altered connectivity in brain networks. While measures of amyloid accumulation and …