Reactive astrocyte nomenclature, definitions, and future directions
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling …
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling …
Questions and (some) answers on reactive astrocytes
C Escartin, O Guillemaud, M Carrillo‐de Sauvage - Glia, 2019 - Wiley Online Library
Astrocytes are key cellular partners for neurons in the central nervous system. Astrocytes
react to virtually all types of pathological alterations in brain homeostasis by significant …
react to virtually all types of pathological alterations in brain homeostasis by significant …
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
Astrocytes are critical components of the neurovascular unit that support blood-brain barrier
(BBB) function. Pathological transformation of astrocytes to reactive states can be protective …
(BBB) function. Pathological transformation of astrocytes to reactive states can be protective …
[HTML][HTML] Neurosteroids as regulators of neuroinflammation
Neuroinflammation is a physiological protective response in the context of infection and
injury. However, neuroinflammation, especially if chronic, may also drive …
injury. However, neuroinflammation, especially if chronic, may also drive …
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states
Astrocytes become reactive in response to insults to the central nervous system by adopting
context-specific cellular signatures and outputs, but a systematic understanding of the …
context-specific cellular signatures and outputs, but a systematic understanding of the …
CD49f is a novel marker of functional and reactive human iPSC-derived astrocytes
New methods for investigating human astrocytes are urgently needed, given their critical
role in the central nervous system. Here we show that CD49f is a novel marker for human …
role in the central nervous system. Here we show that CD49f is a novel marker for human …
Glucocerebrosidase and its relevance to Parkinson disease
J Do, C McKinney, P Sharma, E Sidransky - Molecular neurodegeneration, 2019 - Springer
Mutations in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, are
among the most common known genetic risk factors for the development of Parkinson …
among the most common known genetic risk factors for the development of Parkinson …
[HTML][HTML] Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …
Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes
Astrocytes play important roles in neurological disorders such as stroke, injury, and
neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse …
neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse …
Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell …
T Hyvärinen, S Hagman, M Ristola, L Sukki, K Veijula… - Scientific reports, 2019 - nature.com
Astrocyte reactivation has been discovered to be an important contributor to several
neurological diseases. In vitro models involving human astrocytes have the potential to …
neurological diseases. In vitro models involving human astrocytes have the potential to …