Dynamic regulatory features of the protein tyrosine kinases
N Amatya, DY Lin, AH Andreotti - Biochemical Society …, 2019 - portlandpress.com
The SRC, Abelson murine leukemia viral oncogene homolog 1, TEC and C-terminal SRC
Kinase families of non-receptor tyrosine kinases (collectively the Src module kinases) …
Kinase families of non-receptor tyrosine kinases (collectively the Src module kinases) …
Structure‐Guided Drug Design Targeting Abl Kinase: How Structure and Regulation Can Assist in Designing New Drugs
DM Martins, PO Fernandes, LA Vieira… - …, 2024 - Wiley Online Library
The human protein Abelson kinase (Abl), a tyrosine kinase, plays a pivotal role in
developing chronic myeloid leukemia (CML). Abl's involvement in various signaling …
developing chronic myeloid leukemia (CML). Abl's involvement in various signaling …
A switch in nucleotide affinity governs activation of the Src and Tec family kinases
F von Raußendorf, A de Ruiter, TA Leonard - Scientific Reports, 2017 - nature.com
The Tec kinases, closely related to Src family kinases, are essential for lymphocyte function
in the adaptive immune system. Whilst the Src and Abl kinases are regulated by tail …
in the adaptive immune system. Whilst the Src and Abl kinases are regulated by tail …
Identification and characterization of activating ABL1 1b kinase mutations: impact on sensitivity to ATP-competitive and allosteric ABL1 inhibitors
BJ Lee, NP Shah - Leukemia, 2017 - nature.com
Although pathologically activated ABL1 fusion kinases represent well-validated therapeutic
targets, tumor genomic sequencing has identified numerous point mutations in the ABL1 …
targets, tumor genomic sequencing has identified numerous point mutations in the ABL1 …
New heteroleptic ruthenium (II) complexes with sulfamethoxypyridazine and diimines as potential antitumor agents
ACC de Melo, JM Santana, KJRC Nunes… - Molecules, 2019 - mdpi.com
Two new complexes of Ru (II) with mixed ligands were prepared:[Ru (bpy) 2smp](PF6)(1)
and [Ru (phen) 2smp](PF6)(2), in which smp= sulfamethoxypyridazine; bpy= 2, 2 …
and [Ru (phen) 2smp](PF6)(2), in which smp= sulfamethoxypyridazine; bpy= 2, 2 …
Myristoyl's dual role in allosterically regulating and localizing Abl kinase
S de Buhr, F Gräter - Elife, 2023 - elifesciences.org
Abstract c-Abl kinase, a key signaling hub in many biological processes ranging from cell
development to proliferation, is tightly regulated by two inhibitory Src homology domains. An …
development to proliferation, is tightly regulated by two inhibitory Src homology domains. An …
Calculation of the cross-sectional shape of a fibril from equatorial scattering
B Roig-Solvas, L Makowski - Journal of Structural Biology, 2017 - Elsevier
An alternate formulation of helical diffraction theory is used to generate cross-sectional
shapes of fibrous structures from equatorial scattering. We demonstrate this approach with …
shapes of fibrous structures from equatorial scattering. We demonstrate this approach with …
[HTML][HTML] TRIB3 通过抑制CTSZ 介导的BCR-ABL 降解促进急性淋巴细胞白血病疾病进程
再吾力， 叶尔江， 王凤， 杨兆娜， 胡卓伟， 李珂 - 药学学报, 2020 - html.rhhz.net
费城染色体Ph 阳性急性B 淋巴细胞白血病(Ph+ B-ALL) 是最常见的与染色体异常相关的急性
淋巴细胞白血病, 该疾病常发于儿童和青壮年, 其治疗预后效果较差. 研究表明, 假性激酶TRIB3 …
淋巴细胞白血病, 该疾病常发于儿童和青壮年, 其治疗预后效果较差. 研究表明, 假性激酶TRIB3 …
What can we learn from wide-angle solution scattering?
Y Wang, H Zhou, E Onuk, J Badger… - Biological Small Angle …, 2017 - Springer
Extending collection of x-ray solution scattering data into the wide-angle regime (WAXS) can
provide information not readily extracted from small angle (SAXS) data. It is possible to …
provide information not readily extracted from small angle (SAXS) data. It is possible to …
[PDF][PDF] 动静脉特异性内膜增生信号通路的研究现状
付品婷， 邬光敏， 郭媛媛 - 中国普通外科杂志, 2019 - zpwz.net
摘要动脉与静脉不仅仅存在结构与功能的区别, 两者更具有基因水平上的差异,
分子指纹EphrinB2/EphB4 在血管生成和重构中均发挥着重要作用, 选择性干预EphrinB2 …
分子指纹EphrinB2/EphB4 在血管生成和重构中均发挥着重要作用, 选择性干预EphrinB2 …