Metastasis in lung cancer is a multifaceted process. In this review, we will dissect the
process in several isolated steps such as angiogenesis, hypoxia, circulation, and …

The oncogenic epithelial–mesenchymal transition (EMT) contributes to tumor progression in
various context-dependent ways, including increased metastatic potential, expansion of …

We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172
individuals with prostate cancer and 1,157 controls of European origin—nested in the …

Background The main cause of death in colorectal cancer patients is metastasis.
Accumulating evidences suggest that circRNA plays pivotal roles in cancer initiation and …

CtBP1 and CtBP2 are closely related and evolutionarily conserved transcriptional
corepressors. There is strong evidence linking CtBPs to tumorigenesis and tumor …

The PTEN tumour suppressor gene is induced by the early growth response 1 (EGR1)
transcription factor, which also transactivates p53, p73, and p300/CBP as well as other …

Variation in the gut microbiome has been linked to colorectal cancer (CRC), as well as to
host genetic variation. However, we do not know whether, in addition to baseline host …

ABSTRACT C-terminal Binding Proteins (CtBP) 1 and 2 are oncogenic transcriptional co-
regulators overexpressed in many cancer types, with their expression level correlating to …

C-terminal binding proteins (CtBPs) were initially identified as binding partners for the E1A-
transforming proteins. Although the invertebrate genome encodes one CtBP protein, two …

Simple Summary The p53 pathway is a major tumor suppressor pathway that prevents the
propagation of abnormal cells by regulating DNA repair, cell cycle progression, cell death, or …