SARS-CoV-2 infection represents a global threat to human health. Various approaches were
employed to reveal the pathogenetic mechanisms of COVID-19. Mathematical and …

Within-host models of COVID-19 infection dynamics enable the merits of different forms of
antiviral therapy to be assessed in individual patients. A stochastic agent-based model of …

Hepatitis B virus (HBV) is a global health threat, and its elimination by 2030 has been
prioritised by the World Health Organisation. Here we present an age-structured model for …

Despite a vaccine, hepatitis B virus (HBV) remains a world-wide source of infections and
deaths. We develop a whole-cell computational platform combining spatial and kinetic …

Hepatitis B virus infection is a deadly liver disease. A part of newly produced HBV DNA-
containing capsids are reused as a core particle in HBV replication. It is investigated that the …

The roles of RNA sequence/structure motifs, Packaging Signals (PSs), for regulating
assembly of an HBV genome transcript have been investigated in an efficient in vitro assay …

Analysis of cell population can reveal the average information about the viral infection in
host whereas single-cell analysis can capture the individual consideration. Single-cell …

Hepatitis B virus (HBV) infection is a deadly liver disease. The main aim of this work is to
explore the role of cytoplasmic recycling of rcDNA-containing capsids in the hepatitis B virus …

Antiviral treatments against hepatitis B virus (HBV) suppress viral replication but do not
eradicate the virus, and need therefore to be taken lifelong to avoid relapse. Mathematical …

RNA sequences/motifs dispersed across the genome of Hepatitis B Virus regulate formation
of nucleocapsid-like particles (NCPs) by core protein (Cp) in vitro, in an epsilon/polymerase …