Many successful stories in enzyme engineering are based on the creation of randomized
diversity in large mutant libraries, containing millions to billions of enzyme variants. Methods …

Endoplasmic reticulum (ER) is an indispensable organelle in eukaryotic cells involved in
protein synthesis and processing, as well as calcium storage and release. Therefore …

In this work, tetrahydro-acridine salt hybrid coumarin dyes was designed and developed as
a Near-infrared (NIR) fluorescent probe CM for the detection and fluorescent bioimaging of …

The formation of amorphous misfolded and aggregated proteins is a hallmark of proteome
stress in diseased cells. Given its lack of defined targeting sites, the rational design of …

The endoplasmic reticulum (ER) is the most widespread organelle within eukaryotic cells,
performing various essential functions such as protein synthesis, post-translational …

Covalent sensors to detect and capture aggregated proteome in stressed cells are rare.
Herein, we construct a series of covalent fluorogenic sensors for aggregated proteins by …

Due to their capability for sensing changes in viscosity, fluorescent molecular rotors (FMRs)
have emerged as potential tools to develop several promising viscosity probes; most of …

Abstract Hydrogen peroxide (H 2 O 2) plays vital roles in oxidative stress and signal
transduction in living organisms, and its abnormal levels could be linked to many diseases …

The direct incorporation of borondipyrromethene (BODIPY) subunits into the structural
backbone of covalent organic frameworks (COFs) gives facile access to porous …

Protein phase separation process involving protein unfolding, misfolding, condensation and
aggregation etc. has been associated with numerous human degenerative diseases. The …