Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

The formation of the nervous system involves establishing complex networks of synaptic
connections between proper partners. This developmental undertaking requires the rapid …

Developmental axon branching dramatically increases synaptic capacity and neuronal
surface area. Netrin-1 promotes branching and synaptogenesis, but the mechanism by …

The function of soluble N-ethylmaleimide-sensitive factor attachment protein receptors
(SNAREs) in cellular trafficking, membrane fusion and vesicle release in synaptic nerve …

Glioblastoma (GBM) is the most prevalent adult brain tumor, with virtually no cure, and with a
median overall survival of 15 months from diagnosis despite of the treatment. SNARE …

Abstract Background The Zic family of transcription factors (TFs) promote both proliferation
and maturation of cerebellar granule neurons (CGNs), raising the question of how a single …

The nervous system has a highly complex organization, including many cell types with
multiple functions, with an intricate anatomy and unique structural and functional …

Brain formation requires the establishment of complex neural circuits between a diverse
array of neuronal subtypes in an intricate and ever changing microenvironment and yet with …

During development, neurons progress through rapid yet stereotypical shape changes to
achieve proper neuronal connectivity. This morphological progression requires carefully …

Through complex mechanisms that guide axons to the appropriate routes towards their
targets, axonal growth and guidance lead to neuronal system formation. These mechanisms …