Neisseria gonorrhoeae (a Gram-negative diplococcus) is a human pathogen and causative agent of gonorrhea, a sexually transmitted infection. The bacterium uses various …
The 8-oxo-7, 8-dihydroguanine, referred to as 8-oxoG, is a highly mutagenic DNA lesion that can provoke the appearance of mismatches if it escapes the DNA Damage Response. The …
Y Li, YC Guo, HH Cheng, X Zeng… - Proteins: Structure …, 2022 - Wiley Online Library
Human immunodeficiency virus (HIV) exploits the sequence variation and structural dynamics of the envelope glycoprotein gp120 to evade the immune attack of neutralization …
J Morere, C Hognon, T Miclot, T Jiang… - Journal of Chemical …, 2022 - ACS Publications
The stimulator of interferon genes (STING) protein is a cornerstone of the human immune response. Its activation by cGAMP in the presence of cytosolic DNA stimulates the …
After a sudden and first spread of the pandemic caused by the novel SARS-CoV-2 (Severe Acute Respiratory Syndrome—Coronavirus 2) wild-type strain, mutants have emerged which …
N Gillet, E Dumont - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Oxidatively generated lesions such as 8-oxo-7, 8-dihydroguanine (8-oxoG) on RNA strands constitute a hallmark marker of the oxidative stress in the cell. Poly-C binding protein 1 …
In the last few years, the sudden outbreak of COVID-19 caused by SARS-CoV-2 proved the crucial importance of understanding how emerging viruses work and proliferate, in order to …
J Kaźmierczak-Barańska, K Boguszewska… - Cells, 2021 - mdpi.com
Clustered DNA lesions (CDL) containing 5′, 8-cyclo-2′-deoxypurines (cdPus) are an example of extensive abnormalities occurring in the DNA helix and may impede cellular …
Y Karami, E Bignon - Computational and Structural Biotechnology Journal, 2024 - Elsevier
Gene activity is tightly controlled by reversible chemical modifications called epigenetic marks, which are of various types and modulate gene accessibility without affecting the DNA …