Oxidatively generated tandem DNA modifications by pyrimidinyl and 2-deoxyribosyl peroxyl radicals

G Robert, JR Wagner, J Cadet - Free Radical Biology and Medicine, 2023 - Elsevier
Molecular oxygen sensitizes DNA to damage induced by ionizing radiation, Fenton-like
reactions, and other free radical-mediated reactions. It rapidly converts carbon-centered …

Neisseria gonorrhoeae: DNA Repair Systems and Their Role in Pathogenesis

VY Savitskaya, MV Monakhova, IV Iakushkina… - Biochemistry …, 2022 - Springer
Neisseria gonorrhoeae (a Gram-negative diplococcus) is a human pathogen and causative
agent of gonorrhea, a sexually transmitted infection. The bacterium uses various …

Molecular mechanisms associated with clustered lesion-induced impairment of 8-oxoG recognition by the human glycosylase OGG1

T Jiang, A Monari, E Dumont, E Bignon - Molecules, 2021 - mdpi.com
The 8-oxo-7, 8-dihydroguanine, referred to as 8-oxoG, is a highly mutagenic DNA lesion that
can provoke the appearance of mismatches if it escapes the DNA Damage Response. The …

Deciphering gp120 sequence variation and structural dynamics in HIV neutralization phenotype by molecular dynamics simulations and graph machine learning

Y Li, YC Guo, HH Cheng, X Zeng… - Proteins: Structure …, 2022 - Wiley Online Library
Human immunodeficiency virus (HIV) exploits the sequence variation and structural
dynamics of the envelope glycoprotein gp120 to evade the immune attack of neutralization …

How fragile we are: Influence of stimulator of interferon genes (STING) variants on pathogen recognition and immune response efficiency

J Morere, C Hognon, T Miclot, T Jiang… - Journal of Chemical …, 2022 - ACS Publications
The stimulator of interferon genes (STING) protein is a cornerstone of the human immune
response. Its activation by cGAMP in the presence of cytosolic DNA stimulates the …

Revealing the Molecular Interactions between Human ACE2 and the Receptor Binding Domain of the SARS-CoV-2 Wild-Type, Alpha and Delta Variants

C Hognon, E Bignon, A Monari, M Marazzi… - International Journal of …, 2023 - mdpi.com
After a sudden and first spread of the pandemic caused by the novel SARS-CoV-2 (Severe
Acute Respiratory Syndrome—Coronavirus 2) wild-type strain, mutants have emerged which …

Dynamics and energetics of PCBP1 binding to severely oxidized RNA

N Gillet, E Dumont - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Oxidatively generated lesions such as 8-oxo-7, 8-dihydroguanine (8-oxoG) on RNA strands
constitute a hallmark marker of the oxidative stress in the cell. Poly-C binding protein 1 …

Specific Recognition of the 5′-Untranslated Region of West Nile Virus Genome by Human Innate Immune System

E Bignon, M Marazzi, T Miclot, G Barone, A Monari - Viruses, 2022 - mdpi.com
In the last few years, the sudden outbreak of COVID-19 caused by SARS-CoV-2 proved the
crucial importance of understanding how emerging viruses work and proliferate, in order to …

Effects of 5′, 8′-cyclo-2′-deoxypurines on the base excision repair of clustered DNA lesions in nuclear extracts of the XPC cell line

J Kaźmierczak-Barańska, K Boguszewska… - Cells, 2021 - mdpi.com
Clustered DNA lesions (CDL) containing 5′, 8-cyclo-2′-deoxypurines (cdPus) are an
example of extensive abnormalities occurring in the DNA helix and may impede cellular …

[HTML][HTML] Cysteine hyperoxidation rewires communication pathways in the nucleosome and destabilizes the dyad

Y Karami, E Bignon - Computational and Structural Biotechnology Journal, 2024 - Elsevier
Gene activity is tightly controlled by reversible chemical modifications called epigenetic
marks, which are of various types and modulate gene accessibility without affecting the DNA …