Induced pluripotent stem cells (iPSCs)—roles in regenerative therapies, disease modelling and drug screening

MAM Aboul-Soud, AJ Alzahrani, A Mahmoud - Cells, 2021 - mdpi.com
The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution
to the field of regenerative medicine, paving way for identifying the true potential of human …

MSC based therapies—new perspectives for the injured lung

J Behnke, S Kremer, T Shahzad, CM Chao… - Journal of clinical …, 2020 - mdpi.com
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …

Hyaluronic acid hydrogel integrated with mesenchymal stem cell‐secretome to treat endometrial injury in a rat model of Asherman's syndrome

F Liu, S Hu, H Yang, Z Li, K Huang, T Su… - Advanced …, 2019 - Wiley Online Library
Stem cell therapies have made strides toward the efficacious treatment of injured
endometrium and the prevention of intrauterine adhesions, or Asherman's syndrome (AS) …

Mesenchymal stem cells as a cornerstone in a galaxy of intercellular signals: basis for a new era of medicine

S Fernández-Francos, N Eiro, LA Costa… - International journal of …, 2021 - mdpi.com
Around 40% of the population will suffer at some point in their life a disease involving tissue
loss or an inflammatory or autoimmune process that cannot be satisfactorily controlled with …

Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia

DE Surate Solaligue… - … of Physiology-Lung …, 2017 - journals.physiology.org
The objective of lung development is to generate an organ of gas exchange that provides
both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly …

Mesenchymal stem cell-based therapy as an alternative to the treatment of acute respiratory distress syndrome: current evidence and future perspectives

S Fernández-Francos, N Eiro… - International journal of …, 2021 - mdpi.com
Acute respiratory distress syndrome (ARDS) represents a current challenge for medicine
due to its incidence, morbidity and mortality and, also, the absence of an optimal treatment …

Extracellular matrix remodelling in COPD

M Karakioulaki, E Papakonstantinou… - European Respiratory …, 2020 - Eur Respiratory Soc
The extracellular matrix (ECM) of the lung plays several important roles in lung function, as it
offers a low resistant pathway that allows the exchange of gases, provides compressive …

[HTML][HTML] Stem cell therapies for chronic obstructive pulmonary disease: current status of pre-clinical studies and clinical trials

Z Sun, F Li, X Zhou, KF Chung, W Wang… - Journal of thoracic …, 2018 - ncbi.nlm.nih.gov
Chronic obstructive pulmonary disease (COPD) is a respiratory disease that has a major
impact worldwide. The currently-available drugs mainly focus on relieving the symptoms of …

[HTML][HTML] Cellular stress responses and dysfunctional Mitochondrial–cellular senescence, and therapeutics in chronic respiratory diseases

M Manevski, T Muthumalage, D Devadoss, IK Sundar… - Redox Biology, 2020 - Elsevier
The abnormal inflammatory responses due to the lung tissue damage and ineffective
repair/resolution in response to the inhaled toxicants result in the pathological changes …

Regeneration capability of neonatal lung-derived decellularized extracellular matrix in an emphysema model

K Devi, MS Tomar, M Barsain, A Shrivastava… - Journal of Controlled …, 2024 - Elsevier
Impaired and limited alveolar regeneration upon injury advances pulmonary disorders and
irreversibly affects millions of people worldwide. Adult mammals do not have a strong …