Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for
the efficient propagation of action potentials. During developmental myelination of the …

Cholesterol is an essential component of all cell membranes and particularly enriched in
myelin membranes. Myelin membranes are a major target of immune attacks in the chronic …

Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis
and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously …

Single-cell transcriptomics provide a systematic map of gene expression in different human
cell types. The next challenge is to systematically understand cell-type-specific gene …

Detailed characterization of the cell types in the human brain requires scalable experimental
approaches to examine multiple aspects of the molecular state of individual cells, as well as …

Long non-coding RNAs (lncRNAs) are under active investigation in the development of
cancers, including gastric cancer (GC). Oncogenic autophagy is required for cancer cell …

Background The mechanism underlying breast cancer stem cell (BCSCs) characteristics
remains to be fully elucidated. Accumulating evidence implies that long noncoding RNAs …

Background Domesticated from gray wolves between 10 and 40 kya in Eurasia, dogs
display a vast array of phenotypes that differ from their ancestors, yet mirror other …

Mutations in CHD7, encoding ATP-dependent chromodomain helicase DNA-binding protein
7, in CHARGE syndrome lead to multiple congenital anomalies, including craniofacial …

A lack of sufficient oligodendrocyte myelination contributes to remyelination failure in
demyelinating disorders. miRNAs have been implicated in oligodendrogenesis; however …