The pathophysiology of glaucoma is complex, multifactorial and not completely understood.
Elevated intraocular pressure (IOP) and/or impaired retinal blood flow may cause initial optic …

The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the
precise roles are not known. Understanding these complex processes, which may also be a …

Astrocytes regulate neuroinflammatory responses after stroke and in other neurological
diseases. Although not all astrocytic responses reduce inflammation, their predominant …

Glaucoma is a complex neurodegenerative disease with many clinical subtypes. Some of its
rare forms include pigmentary glaucoma, uveitic glaucoma and congenital glaucoma. While …

Glaucoma is a multifactorial neurodegenerative disorder affecting 80 million people
worldwide. Loss of retinal ganglion cells and degeneration of their axons in the optic nerve …

The exact mechanism of retinal ganglion cell loss in the pathogenesis of glaucoma is yet to
be understood. Mitochondrial damage‐associated molecular patterns (DAMPs) resulting …

Pyroptosis is a lytic form of programmed cell death mediated by gasdermins (GSDMs) with
pore-forming activity in response to certain exogenous and endogenous stimuli. The …

Glial cells are multifunctional, non-neuronal components of the central nervous system with
diverse phenotypes that have gained much attention for their close involvement in …