Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
Discovery, mechanisms of action and combination therapy of artemisinin
Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …
especially in Africa. Throughout history, antimalarial medicines have been one of the most …
REAPR: a universal tool for genome assembly evaluation
Methods to reliably assess the accuracy of genome sequence data are lacking. Currently
completeness is only described qualitatively and mis-assemblies are overlooked. Here we …
completeness is only described qualitatively and mis-assemblies are overlooked. Here we …
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Chemogenetic characterization through in vitro evolution combined with whole-genome
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …
A major genome region underlying artemisinin resistance in malaria
IH Cheeseman, BA Miller, S Nair, S Nkhoma, A Tan… - science, 2012 - science.org
Evolving resistance to artemisinin-based compounds threatens to derail attempts to control
malaria. Resistance has been confirmed in western Cambodia and has recently emerged in …
malaria. Resistance has been confirmed in western Cambodia and has recently emerged in …
PfCRT and its role in antimalarial drug resistance
Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …
Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum
The malaria parasite Plasmodium falciparum has a great capacity for evolutionary
adaptation to evade host immunity and develop drug resistance. Current understanding of …
adaptation to evade host immunity and develop drug resistance. Current understanding of …
Decreasing pfmdr1 Copy Number in Plasmodium falciparum Malaria Heightens Susceptibility to Mefloquine, Lumefantrine, Halofantrine, Quinine, and Artemisinin
ABS Sidhu, AC Uhlemann… - The Journal of …, 2006 - academic.oup.com
The global dissemination of drug-resistant Plasmodium falciparum is spurring intense efforts
to implement artemisinin (ART)–based combination therapies for malaria, including …
to implement artemisinin (ART)–based combination therapies for malaria, including …
Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study
M Roestenberg, AC Teirlinck, MBB McCall, K Teelen… - The Lancet, 2011 - thelancet.com
Background We have shown that immunity to infection with Plasmodium falciparum can be
induced experimentally in malaria-naive volunteers through immunisation by bites of …
induced experimentally in malaria-naive volunteers through immunisation by bites of …
Antibodies against Plasmodium falciparum malaria at the molecular level
JP Julien, H Wardemann - Nature Reviews Immunology, 2019 - nature.com
Malaria is a vector-borne disease of global importance, with the vast majority of its life-
threatening cases caused by infection with Plasmodium falciparum parasites. Repeated …
threatening cases caused by infection with Plasmodium falciparum parasites. Repeated …