Hydroxychloroquine in the COVID-19 pandemic era: in pursuit of a rational use for prophylaxis of SARS-CoV-2 infection

M Infante, C Ricordi, R Alejandro… - Expert review of anti …, 2021 - Taylor & Francis
Introduction Over the last few months, coronavirus disease 2019 (COVID-19) pandemic
caused by the novel coronavirus SARS-CoV-2 has posed a serious threat to public health …

The lysosome as a master regulator of iron metabolism

F Rizzollo, S More, P Vangheluwe… - Trends in biochemical …, 2021 - cell.com
Intracellular iron fulfills crucial cellular processes, including DNA synthesis and
mitochondrial metabolism, but also mediates ferroptosis, a regulated form of cell death …

Remdesivir and EIDD-1931 interact with human equilibrative nucleoside transporters 1 and 2: implications for reaching SARS-CoV-2 viral sanctuary sites

SR Miller, ME McGrath, KM Zorn, S Ekins… - Molecular …, 2021 - ASPET
Equilibrative nucleoside transporters (ENTs) are present at the blood-testis barrier (BTB),
where they can facilitate antiviral drug disposition to eliminate a sanctuary site for viruses …

Can the shape of nanoparticles enable the targeting to cancer cells over healthy cells?

VT Cong, W Wang, RD Tilley… - Advanced Functional …, 2021 - Wiley Online Library
Macropinocytosis is a consequence of oncogenic alterations of cancer cells while most
healthy cells are non‐macropinocytic. It is currently unclear whether macropinocytic cancer …

Human lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response

E Saygili, E Yildiz-Ozturk, MJ Green… - …, 2021 - pubs.aip.org
Respiratory viral infections are leading causes of death worldwide. A number of human
respiratory viruses circulate in all age groups and adapt to person-to-person transmission. It …

Identifikasi Kemampuan Guru PAUD sebagai Guru Penggerak di Pekanbaru

AK Sembiring, M Dinata… - Jurnal Obsesi: Jurnal …, 2023 - repository.unilak.ac.id
Perubahan paradigma terhadap dunia pendidikan di Indonesia saat ini tidak terlepas dari
dorongan di awal masa kedudukan kementerian, Menteri Pendidikan dan Kebudayaan …

Inclusion complexation of chloroquine with α and β-cyclodextrin: Theoretical insights from the new B97-3c composite method

IM Assaba, S Rahali, Y Belhocine, H Allal - Journal of Molecular Structure, 2021 - Elsevier
Inclusion complexes of α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) with chloroquine
drug (CQ) have been explored using the recently developed B97-3c composite method …

How to exploit different endocytosis pathways to allow selective delivery of anticancer drugs to cancer cells over healthy cells

VT Cong, RD Tilley, G Sharbeen, PA Phillips… - Chemical …, 2021 - pubs.rsc.org
It was recently shown that it is possible to exploit the nanoparticle shape to selectively target
endocytosis pathways found in cancer and not healthy cells. It is important to understand …

Mechanism of blood–heart-barrier leakage: implications for covid-19 induced cardiovascular injury

RP Homme, AK George, M Singh… - International Journal of …, 2021 - mdpi.com
Although blood–heart-barrier (BHB) leakage is the hallmark of congestive (cardio-
pulmonary) heart failure (CHF), the primary cause of death in elderly, and during viral …

Combining hydroxychloroquine and minocycline: potential role in moderate to severe COVID-19 infection

SS Gautam, CS Gautam, VK Garg… - Expert Review of Clinical …, 2020 - Taylor & Francis
Introduction Patients with moderate to severe COVID-19 infection require specific drugs to
prevent the morbidity and mortality. Hydroxychloroquine (HCQ) has shown some promise in …