[HTML][HTML] Targeting the PI3K/Akt pathway in prostate cancer: challenges and opportunities

P Toren, A Zoubeidi - International journal of oncology, 2014 - spandidos-publications.com
Abstract The PI3K/Akt pathway is an actively pursued therapeutic target in oncology. In
prostate cancer, the activation of this pathway appears to be characteristic of many …

The extended human PTP ome: A growing tyrosine phosphatase family

A Alonso, R Pulido - The FEBS journal, 2016 - Wiley Online Library
Tyr phosphatases are, by definition, enzymes that dephosphorylate phospho‐Tyr (pT yr)
from proteins. This activity is found in several structurally diverse protein families, including …

[PDF][PDF] Wang

Y Wang - Jia Z, Yi Q, Song L. The various components implied …, 2018 - tranassoc.com
Systems and methods are disclosed for communicating data in an integrated sensor network
having one or more nodes coupled to an optical sensor network and a radio frequency …

[HTML][HTML] Chimeric antigen receptor-modified T cells therapy in prostate cancer: A comprehensive review on the current state and prospects

M He, D Zhang, Y Cao, C Chi, Z Zeng, X Yang, G Yang… - Heliyon, 2023 - cell.com
Recent immunotherapy research has focused on chimeric antigen receptor-modified T cells
(CAR-Ts). CAR-T therapies have been clinically applied to manage hematologic …

An RNA-Seq-based framework for characterizing canine prostate cancer and prioritizing clinically relevant biomarker candidate genes

H Thiemeyer, L Taher, JT Schille, EM Packeiser… - International journal of …, 2021 - mdpi.com
Prostate cancer (PCa) in dogs is a highly malignant disease akin to its human counterpart. In
contrast to the situation in humans, multi-gene approaches facilitating risk stratification of …

ERK 1/2 activation mediates the neuroprotective effect of BpV (pic) in focal cerebral ischemia–reperfusion injury

R Liu, JC Tang, MX Pan, Y Zhuang, Y Zhang… - Neurochemical …, 2018 - Springer
Abstract Bisperoxovanadium (pyridine-2-carboxyl)[bpV (pic)] is a commercially available
PTEN inhibitor. Previous studies from us and others have shown that bpV (pic) confers …

Molecular biomarkers in prostate cancer tumorigenesis and clinical relevance

NO Alqualo, E Campos-Fernandez, BU Picolo… - Critical Reviews in …, 2024 - Elsevier
Prostate cancer (PCa) is the second most frequent type of cancer in men and assessing
circulating tumor cells (CTCs) by liquid biopsy is a promising tool to help in cancer early …

In-depth glycoproteomic assay of urinary prostatic acid phosphatase

W Wang, CR de Nier, M Wuhrer… - ACS Measurement …, 2023 - ACS Publications
Prostate-specific antigen (PSA) is a well-known clinical biomarker in prostate cancer (PCa)
diagnosis, but a better test is still needed, as the serum-level-based PSA quantification …

Detection of aggressive prostate cancer associated glycoproteins in urine using glycoproteomics and mass spectrometry

X Jia, J Chen, S Sun, W Yang, S Yang, P Shah… - …, 2016 - Wiley Online Library
Clinical management of prostate cancer remains a significant challenge due to the lack of
available tests for guiding treatment decisions. The blood prostate‐specific antigen test has …

HMGB1‐Induced Cross Talk between PTEN and miRs 221/222 in Thyroid Cancer

S Mardente, E Mari, I Massimi, F Fico… - BioMed Research …, 2015 - Wiley Online Library
High mobility group box 1 (HMGB1) is an ubiquitous protein that plays different roles in the
nucleus, cytoplasm, and extracellular space. It is an important DAMP molecule that allows …