Osteoporosis is a skeletal disorder characterized by decreased mass and compromised
bone strength predisposing to an increased risk of fractures. Although idiopathic …

Vitamin D (VD) is essential for bone homeostasis, but it is also involved in pleiotropic effects
on various organs and tissues. In adults, VD deficiency can cause or exacerbate …

Purpose The aim of the International Myeloma Working Group was to develop practice
recommendations for the management of multiple myeloma (MM)–related bone disease …

Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma
cell dyscrasia that consistently precedes multiple myeloma (MM) with a 1% risk of …

Summary In this Policy Review, the Bone Working Group of the International Myeloma
Working Group updates its clinical practice recommendations for the management of …

Monoclonal gammopathy of undetermined significance is one of the most common pre-
malignant disorders. IgG and IgA monoclonal gammopathy of undetermined significance are …

Multiple myeloma is rarely curable and its interactions with the bone marrow
microenvironment are evident. However, separating cause from effect remains a challenge …

Background: Multiple myeloma (MM) is a hematological malignancy characterized by the
exponential growth of malignant plasma cells. Individuals diagnosed with MM exhibit a …

Prior research establishing that bone interacts in coordination with the bone marrow
microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on …

Patients with asymptomatic (smoldering) multiple myeloma (AMM) have a high risk of
transformation to active multiple myeloma (MM). Bisphosphonates such as zoledronic acid …