The endocannabinoid system: a potential target for the treatment of various diseases

H Lowe, N Toyang, B Steele, J Bryant… - International journal of …, 2021 - mdpi.com
The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

Early phytocannabinoid chemistry to endocannabinoids and beyond

R Mechoulam, LO Hanuš, R Pertwee… - Nature Reviews …, 2014 - nature.com
Isolation and structure elucidation of most of the major cannabinoid constituents—including
Δ9-tetrahydrocannabinol (Δ9-THC), which is the principal psychoactive molecule in …

Gut microbiota mediates the protective effects of dietary capsaicin against chronic low-grade inflammation and associated obesity induced by high-fat diet

C Kang, B Wang, K Kaliannan, X Wang, H Lang, S Hui… - MBio, 2017 - Am Soc Microbiol
Metabolic endotoxemia originating from dysbiotic gut microbiota has been identified as a
primary mediator for triggering the chronic low-grade inflammation (CLGI) responsible for …

Modulating the endocannabinoid system in human health and disease–successes and failures

P Pacher, G Kunos - The FEBS journal, 2013 - Wiley Online Library
The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …

Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities

RG Pertwee - … Transactions of the Royal Society B …, 2012 - royalsocietypublishing.org
Human tissues express cannabinoid CB1 and CB2 receptors that can be activated by
endogenously released 'endocannabinoids' or exogenously administered compounds in a …

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

P Pacher, R Mechoulam - Progress in lipid research, 2011 - Elsevier
The mammalian body has a highly developed immune system which guards against
continuous invading protein attacks and aims at preventing, attenuating or repairing the …

The role of the endocannabinoid system in the brain–gut axis

KA Sharkey, JW Wiley - Gastroenterology, 2016 - Elsevier
The actions of cannabis are mediated by receptors that are part of an endogenous
cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring …

Cannabinoids and the gut: new developments and emerging concepts

AA Izzo, KA Sharkey - Pharmacology & therapeutics, 2010 - Elsevier
Cannabis has been used to treat gastrointestinal (GI) conditions that range from enteric
infections and inflammatory conditions to disorders of motility, emesis and abdominal pain …

Cannabinoid hyperemesis syndrome

JA Galli, R Andari Sawaya… - Current drug abuse …, 2011 - ingentaconnect.com
Coinciding with the increasing rates of cannabis abuse has been the recognition of a new
clinical condition known as Cannabinoid Hyperemesis Syndrome. Cannabinoid …

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

RG Pertwee - British journal of pharmacology, 2009 - Wiley Online Library
Mandarin translation of abstract Medicines that activate cannabinoid CB1 and CB2 receptor
are already in the clinic. These are Cesamet®(nabilone), Marinol®(dronabinol; Δ9 …