Harmful effects of nicotine

A Mishra, P Chaturvedi, S Datta… - Indian Journal of …, 2015 - thieme-connect.com
With the advent of nicotine replacement therapy, the consumption of the nicotine is on the
rise. Nicotine is considered to be a safer alternative of tobacco. The IARC monograph has …

Exploiting the critical perioperative period to improve long-term cancer outcomes

M Horowitz, E Neeman, E Sharon… - Nature reviews Clinical …, 2015 - nature.com
Evidence suggests that the perioperative period and the excision of the primary tumour can
promote the development of metastases—the main cause of cancer-related mortality. This …

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

N Shrine, AG Izquierdo, J Chen, R Packer, RJ Hall… - Nature …, 2023 - nature.com
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells

J Liang, M Seghiri, PK Singh, HG Seo… - Proceedings of the …, 2024 - National Acad Sciences
While the existence and functional role of class C G-protein-coupled receptors (GPCR)
dimers is well established, there is still a lack of consensus regarding class A and B GPCR …

Cardiovascular disease and cancer: is there increasing overlap?

L Vincent, D Leedy, SC Masri, RK Cheng - Current oncology reports, 2019 - Springer
Abstract Purpose of Review Cancer and cardiovascular disease are the leading causes of
mortality in the USA. In this review, we highlight these shared disease pathways and provide …

A new approach to reducing postsurgical cancer recurrence: perioperative targeting of catecholamines and prostaglandins

E Neeman, O Zmora, S Ben-Eliyahu - Clinical cancer research, 2012 - AACR
Surgery is a crucial intervention in most cancer patients, but the perioperative period is
characterized by increased risks for future outbreak of preexisting micrometastases and the …

Circadian rhythms and tumor growth

MW Greene - Cancer letters, 2012 - Elsevier
Hormone secretion, metabolism, and the cell cycle are under rhythmic control. Lack of
rhythmic control has been predicted to lead to uncontrolled proliferation and cancer …

β-Adrenergic modulation of cancer cell proliferation: available evidence and clinical perspectives

M Coelho, C Soares-Silva, D Brandão, F Marino… - Journal of cancer …, 2017 - Springer
Purpose In this review, we aimed to present and discuss the available preclinical and
epidemiological evidences regarding the modulation of cancer cell proliferation by β …

[HTML][HTML] Antiproliferative effects of β-blockers on human colorectal cancer cells

M Coelho, M Moz, G Correia, A Teixeira… - Oncology …, 2015 - spandidos-publications.com
Colon cancer is the fourth and third most common cancer, respectively in men and women
worldwide and its incidence is on the increase. Stress response has been associated with …

β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation

G Bruno, F Cencetti, A Pini, A Tondo, D Cuzzubbo… - Oncogene, 2020 - nature.com
Neuroblastoma (NB) is the most frequently observed among extracranial pediatric solid
tumors. It displays an extreme clinical heterogeneity, in particular for the presentation at …