Estrogens play an important role in the regulation of normal physiology, aging and many
disease states. Although the nuclear estrogen receptors have classically been described to …

Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …

The advent of click chemistry has had a profound influence on almost all branches of
chemical science. This is particularly true of radiochemistry and the synthesis of agents for …

Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …

Bio-imaging, by enabling the visualization of biomolecules of interest, has proved to be
highly informative in the study of biological processes. Although fluorescence microscopy is …

The G protein-coupled estrogen receptor (GPER) is a 7-transmembrane receptor implicated
in rapid estrogen signaling. Originally cloned from vascular endothelial cells, GPER plays a …

Background: Many rhenium (Re) complexes with potential anticancer properties have been
synthesized in the recent years with the aim to overcome the clinical limitations of platinum …

The Click-to-Chelate approach is a highly efficient strategy for the radiolabeling of molecules
of medicinal interest with technetium and rhenium-tricarbonyl cores. Reaction of azide …

Studies concerning the development of radiopharmaceuticals based on the Tc (I) carbonyl
core are considered from the coordination-chemical viewpoint. The coordination behavior of …

3-Methoxy-17α-ethynylestradiol or mestranol is a prodrug for ethynylestradiol and the
estrogen component of some oral contraceptive formulations. We demonstrate here that a …