The roles of FLT3 in hematopoiesis and leukemia
DG Gilliland, JD Griffin - Blood, The Journal of the American …, 2002 - ashpublications.org
FLT3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is
important for the normal development of stem cells and the immune system. The ligand for …
important for the normal development of stem cells and the immune system. The ligand for …
Genetics of myeloid leukemias
LM Kelly, DG Gilliland - Annual review of genomics and human …, 2002 - annualreviews.org
▪ Abstract Human leukemias are typified by acquired recurring chromosomal translocations.
Cloning of these translocation breakpoints has provided important insights into …
Cloning of these translocation breakpoints has provided important insights into …
C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
M Sabatier, R Birsen, L Lauture, S Mouche, P Angelino… - Cancer Discovery, 2023 - AACR
Although transcription factor CCAAT-enhancer binding protein α (C/EBPα) is critical for
normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely …
normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely …
[HTML][HTML] Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
E Weisberg, C Boulton, LM Kelly, P Manley, D Fabbro… - Cancer cell, 2002 - cell.com
Constitutively activating FLT3 receptor mutations have been found in 35% of patients with
acute myeloblastic leukemia (AML). Here we report the identification of a small molecule …
acute myeloblastic leukemia (AML). Here we report the identification of a small molecule …
Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
BD Smith, M Levis, M Beran, F Giles, H Kantarjian… - Blood, 2004 - ashpublications.org
Activating mutations of FMS-like tyrosine kinase 3 (FLT3) are present in approximately 30%
of patients with de novo acute myeloid leukemia (AML) and are associated with lower cure …
of patients with de novo acute myeloid leukemia (AML) and are associated with lower cure …
Clinical implications of FLT3 mutations in pediatric AML
S Meshinchi, TA Alonzo, DL Stirewalt, M Zwaan… - Blood, 2006 - ashpublications.org
Activating mutations of the FLT3 gene occur because of an internal tandem duplication of
the juxta-membrane domain (FLT3/ITD) or point mutation of the activation loop domain …
the juxta-membrane domain (FLT3/ITD) or point mutation of the activation loop domain …
FLT3 mutations in acute myeloid leukemia cell lines
H Quentmeier, J Reinhardt, M Zaborski, HG Drexler - Leukemia, 2003 - nature.com
Internal tandem duplications (ITD) and D835 point mutations of the receptor tyrosine kinase
(RTK) FLT3 are found in a high proportion of cases with acute myeloid leukemia (AML) …
(RTK) FLT3 are found in a high proportion of cases with acute myeloid leukemia (AML) …
[HTML][HTML] Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications
S Takahashi - Journal of hematology & oncology, 2011 - Springer
FLT3 is a type III receptor tyrosine kinase. Mutations of FLT3 comprise one of the most
frequently identified types of genetic alterations in acute myeloid leukemia. One-third of …
frequently identified types of genetic alterations in acute myeloid leukemia. One-third of …
Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in …
PD Kottaridis, RE Gale, SE Langabeer… - Blood, The Journal …, 2002 - ashpublications.org
FLT3 mutations, either internal tandem duplications (ITDs) or aspartate residue 835 (D835)
point mutations, are present in approximately one third of patients with acute myeloid …
point mutations, are present in approximately one third of patients with acute myeloid …