Saponins in cancer treatment: Current progress and future prospects

OO Elekofehinti, O Iwaloye, F Olawale, EO Ariyo - Pathophysiology, 2021 - mdpi.com
Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming
nature. Different saponins have been characterized and purified and are gaining attention in …

Triterpenoids from the genus Gynostemma: Chemistry and pharmacological activities

NH Nguyen, TKQ Ha, JL Yang, HTT Pham… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance G. pentaphyllum, also known as Jiao-Gu-Lan, has been
used traditionally as folk remedies for many diseases, including diabetes mellitus, metabolic …

Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo

JP Lin, JS Yang, JJ Lin, KC Lai, HF Lu… - Environmental …, 2012 - Wiley Online Library
Numerous studies have shown that rutin has anticancer effects. We have previously
reported that rutin induced cell cycle arrest and apoptosis in murine leukemia WEHI‐3 cells …

Anti-cancerous potential of polysaccharide fractions extracted from peony seed dreg on various human cancer cell lines via cell cycle arrest and apoptosis

F Zhang, JJ Shi, K Thakur, F Hu, JG Zhang… - Frontiers in …, 2017 - frontiersin.org
In this study, four homo/heterogenous polysaccharides (HBSS, CHSS, DASS, and CASS)
extracted from peony seed dreg with respective molecular weights of 3467, 4677, 229, and …

Gypenosides reduced the risk of overweight and insulin resistance in C57BL/6J mice through modulating adipose thermogenesis and gut microbiota

J Liu, Y Li, P Yang, J Wan, Q Chang… - Journal of agricultural …, 2017 - ACS Publications
This study investigated whether and how gypenosides from jiaogulan tea at 100 and 300
mg/kg/day levels could reduce the development of overweight and insulin resistance in C57 …

Gynostemma pentaphyllum an immortal herb with promising therapeutic potential: a comprehensive review on its phytochemistry and pharmacological perspective

A Ahmed, MA Saleem, F Saeed, M Afzaal… - … Journal of Food …, 2023 - Taylor & Francis
Gynostemma pentaphyllum belongs to the family Cucurbitaceae which is native to China
where it is also termed an immortal herb. It is an emerging herb gaining fame for its rich …

Syringin exerts neuroprotective effects in a rat model of cerebral ischemia through the FOXO3a/NF-κB pathway

J Tan, J Luo, C Meng, N Jiang, J Cao, J Zhao - International …, 2021 - Elsevier
Inflammation plays an important role in the pathogenesis of cerebral ischemia. Syringin
(SYR) is an active substance isolated from Acanthopanax senticosus plants, and possesses …

Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)

Y Li, W Lin, J Huang, Y Xie, W Ma - Chinese medicine, 2016 - Springer
Abstract Gynostemma pentaphyllum (Thunb.) Makino (GpM)(Jiaogulan) has been widely
used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes …

[HTML][HTML] Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression

X Huang, W Chen, C Yan, R Yang, Q Chen… - Biomedicine & …, 2019 - Elsevier
Gypenosides (GP) are a type of traditional Chinese medicine (TCM) extracted from plants
and commonly applied for treatment of metabolic diseases. This study aims to explore the …

Medicinal value and potential therapeutic mechanisms of Gynostemma pentaphyllum (Thunb.) Makino and its derivatives: An overview

K Li, C Ma, H Li, S Dev, JF He… - Current topics in medicinal …, 2019 - ingentaconnect.com
Gynostemma pentaphyllum (Thunb.) Makino (GpM) and its derivatives, especially
gypenosides (Gyps), are widely used as safe and convenient natural herbal drugs for the …