Lipohypertrophy and insulin: an old dog that needs new tricks

J Huang, AM Yeung, D Kerr, S Gentile, L Heinemann… - Endocrine Practice, 2023 - Elsevier
Objective To review the current status of practical knowledge related to insulin-associated
lipohypertrophy (LH)—an accumulation of fatty subcutaneous nodules commonly caused by …

Relationship between lipohypertrophy, glycemic control, and insulin dosing: a systematic meta-analysis

JK Mader, R Fornengo, A Hassoun… - Diabetes Technology …, 2024 - liebertpub.com
Background: Lipohypertrophy is a common complication in patients with diabetes receiving
insulin therapy. There is a lack of consensus regarding how much lipohypertrophy affects …

Insulin-induced skin lipohypertrophy in type 2 diabetes: a multicenter regional survey in Southern Italy

S Gentile, G Guarino, TD Corte, G Marino, A Fusco… - Diabetes Therapy, 2020 - Springer
Abstract Introduction Lipohypertrophies (LHs) due to incorrect insulin injection techniques
have been described in the literature for decades. Their rate averages 38%, but this is still …

New ex vivo method to objectively assess insulin spatial subcutaneous dispersion through time during pump basal-rate based administration

P Jacquemier, Y Retory, C Virbel-Fleischman… - Scientific Reports, 2023 - nature.com
Glycemic variability remains frequent in patients with type 1 diabetes treated with insulin
pumps. Heterogeneous spreads of insulin infused by pump in the subcutaneous (SC) tissue …

Insulin‐induced Lipohypertrophy in Patients with Type 1 Diabetes Mellitus Treated with an Insulin Pump

D Ucieklak, S Mrozinska, A Wojnarska… - International Journal …, 2022 - Wiley Online Library
Background. Lipohypertrophy (LH) of subcutaneous tissue is an insulin‐induced
complication occurring in patients with diabetes. We aimed to define the prevalence of LH …

Characteristics and morphology of lipohypertrophic lesions in adults with type 1 diabetes with ultrasound screening: an exploratory observational study

R Hashem, H Mulnier, HA Ghazaleh… - BMJ Open Diabetes …, 2021 - drc.bmj.com
Introduction Lipohypertrophy is a common complication of exposure to insulin therapy.
Despite the prevalence of lipohypertrophy and its potentially hazardous effects on glucose …

Determination of insulin-related lipohypertrophy frequency and risk factors in patients with diabetes

FN Korkmaz, AG Canpolat, S Güllü - Endocrinología, Diabetes y Nutrición …, 2022 - Elsevier
Introduction Insulin, which is used in the treatment of diabetes mellitus (DM), may lead to the
development of lipohypertrophy (LH) which can negatively affect the management of …

Addressing insulin injection technique: a follow-up study of Canadian patients with diabetes

B Bari, MA Corbeil, G MacNeill, S Puebla-Barragan… - Diabetes Therapy, 2023 - Springer
Introduction Proper insulin injection technique is important for optimal glycaemic control, yet
patients with diabetes often inject insulin incorrectly. Previous studies identified common …

A systematic survey of physicians' insights into lipohypertrophy

M Shen, Y Shi, S Zheng, H Fan, J Xu… - Frontiers in Public …, 2021 - frontiersin.org
Background: It is important that physicians be aware of LH. We designed a questionnaire to
determine physician awareness, knowledge, and behaviors regarding LH in clinical …

Subclinical lipohypertrophy——Easily ignored complications of insulin therapy

D Luo, Y Shi, M Zhu, H Wang, D Yan, J Yu, JJ Ji… - Journal of Diabetes and …, 2021 - Elsevier
Aims Subclinical lipohypertrophy is a lesion meeting ultrasonic criteria for lipohypertrophy
that was not detected by inspection and palpation. Little information is published on …